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By Kate Kelland
LONDON (Reuters) - Scientists studying damaged brains of boxers and other sports people have found key details about a head injury-linked disease called "punch drunk syndrome" that could help the development of new diagnostics and treatments for Alzheimer's.
The syndrome, also known as chronic traumatic encephalopathy (CTE), is linked to repeated blows to the head and causes a type of dementia similar to Alzheimer's, which is characterized by behavioral changes, confusion and memory loss.
CTE can affect people who play contact sports such as boxing, rugby, soccer and football, but can currently be diagnosed only after death, since brain tissues have to be removed and analyzed to confirm presence of the disease.
Like Alzheimer's - a brain-wasting condition that affects up to 50 million people worldwide - CTE features the abnormal build-up of certain proteins in the brain. One of those, tau, forms filaments that clump up in tangles inside cells.
In this study, published in the journal Nature on Wednesday, researchers from Britain's Medical Research Council Laboratory of Molecular Biology (LMB) were able to detail the atomic structures of the abnormal tau filaments in CTE.
"Our new knowledge of these structures could make it possible to diagnose CTE in living patients by developing tracer compounds that will specifically bind to the tau filaments of CTE," said Michel Goedert, an LMB researcher who co-led the study.
The research involved scientists extracting tau filaments from the brains of three people with CTE post-mortem - one former professional American football player and two former professional boxers.
The filaments were then imaged using a technique known as cryo-electron microscopy. The team found that while the tau structures from the three patients with CTE were identical, they were also different from those seen in Alzheimer's.
This could in future help doctors distinguish between various forms of dementia when diagnosing patients, the team said, and also furthers understanding of how and why tau forms disease-specific clumps and folds.
"We don't know the chemical nature of these molecules yet, but we suspect they may play a role in the assembly of tau into filaments, and that their abundance may determine why some individuals develop CTE and others do not," said Sjors Scheres, who co-led the work.
He said the next stage of research will be to identify those molecules and understand more about their role in tau build-up.
(Reporting by Kate Kelland; Editing by Frances Kerry)
Link: https://sports.yahoo.com/study-finds-key-details-punch-drunk-syndrome-alzheimers-180147909--nfl.html
Kate Kelland
@kkelland
Award-winning Health and Science Correspondent for Reuters. Also mother of two and aspiring triathlete. Likes: hard work; asking questions; learning new things.
United Kingdom
Joined June 2009
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MARCH 21, 2019
Scientists discover unique tau filament structures in head-injury associated dementia
by Medical Research Council
A cross section of the type-I CTE filament. Credit: MRC-LMB
Researchers at the MRC Laboratory of Molecular Biology (LMB) have revealed the atomic structures of the abnormal tau filaments associated with chronic traumatic encephalopathy (CTE), a head injury-associated neurodegenerative disease, and found that they differ in structure from those seen in Alzheimer's disease.
The study, published in the journal Nature, could lead to improved diagnosis of the disease, which is often not made until after death, and the development of new treatments to prevent its progression.
CTE is associated with repeated blows to the head, particularly in relation to contact sports, such as boxing, rugby and football. The symptoms of CTE include behavioural changes, confusion and memory loss. The exact causes of the disease are not fully understood however, and it is not known why only some people exposed to repeated head injury appear to develop the disease. The condition was first described in the 1920s and was known as 'punch drunk syndrome,' and later dementia pugilistica, because some ex-boxers developed dementia.
Two years ago, the same group of scientists at the LMB revealed for the first time the atomic structures of the tau filaments which lead to Alzheimer's disease. CTE, like Alzheimer's, is associated with the abnormal build-up of tau protein in the brain. This study used the same technique to discover that CTE has its own unique structure of tau filaments.
The researchers extracted tau filaments from the brains of three individuals with CTE post-mortem: one former professional American football player and two former professional boxers. The filaments were then imaged using the cryo-electron microscopy facilities at the LMB, Diamond Light Source and the University of Leicester. The team found identical tau structures from the three patients with CTE that were different from those seen in Alzheimer's. One striking difference between the CTE and the Alzheimer filaments was the formation of cavities in the CTE filaments, which are filled with other molecules.
Sjors Scheres, a research leader at the MRC LMB and lead author of the study, said: "We don't know the chemical nature of these molecules yet, but we suspect they may play a role in the assembly of tau into filaments, and that their abundance may determine why some individuals develop CTE and others do not. The next stage of our research will be to identify these molecules and understand more about their role in tau assembly, as they may represent a possible target for drug development."
Michel Goedert, a research leader at the LMB who co-led the study, said: "The fact that the structures of the tau filaments were identical in the American football player and both boxers suggests that we've found a new criterion for post-mortem diagnosis of the disease. Our new knowledge of these structures could make it possible to diagnose CTE in living patients by developing tracer compounds that will specifically bind to the tau filaments of CTE."
Dr. Joanna Latimer, Head of Neurosciences and Mental Health at the MRC, which funded the research, said: "This new work builds on our knowledge of dementia and how different forms of the disease develop in the brain. Further understanding of how and why tau assembles into disease-specific folds will be crucial in the development of new treatments for CTE and other neurodegenerative diseaseswhich involve defective tau."
Explore furtherScientists uncover the structure of tau filaments from Alzheimer's disease
More information: Benjamin Falcon et al. Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules, Nature (2019). DOI: 10.1038/s41586-019-1026-5Provided by Medical Research Council
Link: https://medicalxpress.com/news/2019-03-scientists-unique-tau-filament-head-injury.html
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